Summaries LSBR projects

For the LSBR projects that have been finished since 2015 you can find summaries here. This list of summaries will gradually expand.
For an overview of the all projects since 1999, please see: list of LSBR projects


Grants 2018

Regulatory T cells carry an iron harness to protect their identity (LSBR 1818)
Project leader: Dr Derk Amsen, Hematopoiesis and Immunopathology, Sanquin Research

Disease in a dish: Modelling Von Willebrand disease with patient-specific induced pluripotent stem cells (LSBR 1852)
Project leader: Prof. H.C. Jeroen Eikenboom, Thrombosis and Hemostasis, Leiden University Medical Center


Grants 2017

Enhancing thrombin-mediated activation of factor XI: a novel therapeutic approach to control bleeding? (LSBR 1702)
Project leader: Prof. Joost C.M. Meijers, Plasma Proteins, Sanquin Research

Dissecting the role of Neogenin-1, a novel receptor required for hematopoietic stem cell proliferation and engraftment (LSBR 1703)
Project leader: Prof. Gerald de Haan, European Research Institute for the Biology of Ageing, University Medical Center Groningen

Platelet subsets and priming: functional determinants of haemostasis and vascular protection (LSBR 1711)
Project leader: Prof. Johan W.M. Heemskerk / Dr Paola J.E. van der Meijden, Biochemistry CARIM Maastricht University

“Heme oygenase‐1 keeps graft versus host disease away”: the role of heme oxygenase‐1 in the development of graft versus host disease (LSBR 1719)
Project leaders: Dr Carlijn Voermans, Hematopoiesis and Immunopathology, Sanquin Research and Prof. dr. Sacha S. Zeerleder, Dept. of Hematology – Amsterdam UMC, Academic Medical Center

The Ig-glycan code: a third level of regulation controlling effector function of immunoglobulins in health and disease (LSBR 1721)
Project leader: Dr Gestur Vidarsson, Dept Immunopathology, Sanquin Research


Grants 2016

How to prevent unwanted antibodies; regulation of plasma cell formation by the dynamic interplay between specific B cells and follicular T-helper cells (LSBR 1609)
Project leader: Prof. Marieke van Ham, Sanquin Research, Dept. of Immunopathology, Amsterdam

IgG Fab glycosylation: a novel mediator of humoral tolerance (LSBR 1626)
Project leader: Dr Theo Rispens, Sanquin Research, Dept. of Immunopatholgy, Amsterdam

Repurposing CRISPR/Cas9 for targeted demethylation of the gamma-globin promoters (LSBR 1627)
Project leader: Prof. J.N.J. (Sjaak) Philipsen, Dept. Hematology, Erasmus MC, Rotterdam

Universal and tissue-tailored gene programs of resident memory lymphocytes (LSBR 1629) FELLOWSHIP
Project leader: Dr Klaas van Gisbergen, Dept. of Hematopoiesis, Sanquin Research, Amsterdam

Intercellular communication and immunomodulatory activities of platelet microvesicles in vascular inflammation (LSBR 1638)
Project leader: Dr Rory R. Koenen, CARIM – Maastricht University, Maastricht

Border control at the vessel wall: The endothelium as customs official for leukocyte crossing (LSBR 1649)
Project leader: Prof. Jaap D. van Buul, Sanquin Research, Molecular Cell Biology, Amsterdam


Grants 2015

Interaction between Choline Transporter-like Protein-2 and von Willebrand Factor: Importance to Transfusion-related Acute Lung Injury and Beyond (LSBR 1503)
Project leader: Dr Bart J.M. van Vlijmen, Dept. of Thrombosis and Hemostasis, LUMC, Leiden

Development of RNA-targeted therapies for bleeding disorders, especially von Willebrand disease (LSBR 1504)
Project leader: Prof. Jeroen C.J. Eikenboom, Dept. of Thrombosis and Hemostasis, LUMC, Leiden

Interactions of hemostatic proteins with the vasculature; go with the flow? (LSBR 1517) FELLOWSHIP
Project leader: Dr Maartje van den Biggelaar, Dept. of Plasma Proteins, Sanquin Research, Amsterdam

Plasmin to the rescue in thrombotic thrombocytopenic purpura (LSBR 1520)
Project leader: Dr Coen Maas, Laboratory for Clinical Chemistry and Haematology, UMC Utrecht

Functional dissection of C-reactive protein’s role in exacerbating destruction of blood cells (LSBR 1527)
Project leader: Dr Gestur Vidarsson, Dept. of Experimental Immunohematology, Immunoglobulin research lab Sanquin Research, Amsterdam

Genetics and epigenetics in megakaryopoiesis: the role of GFI1B (LSBR 1531)
Project leader: Project leader: Dr Bert A. van der Reijden (RadboudUMC), Dr. Marieke von Lindern (Sanquin)

Towards a more effective and efficient use of intravenous immunoglobulin in children with immune thrombocytopenia (LSBR 1546)
Project leader: Project leader: Prof. Masja de Haas (Sanquin Research and Leiden University Medical Center)


Grants 2014

Role of RBC adhesion molecules in immune adherence clearance (LSBR 1412)
Project leader: Dr Robin van Bruggen, Dept. of Blood Cell Research, Sanquin Research, Amsterdam

Redesigning coagulation factor VIII; Repairing an evolutionary mistake (LSBR 1417)
Project leader: Prof. Sander (A.B.) Meijer, Dept. of Plasma Proteins, Sanquin Research, Amsterdam

Transgenerational T cells: a form of maternal care after birth with therapeutic potential in allogeneic stem cell therapy (LSBR 1430)
Project leader: Dr Derk Amsen, Dept. of Hematopoiesis, Sanquin Research, Amsterdam

The protective role of innate lymphoid cells (ILC) after hematopoietic stem cell transplantation (LSBR 1438) FELLOWSHIP
Project leader: Dr Mette D. Hazenberg, Hematology, AMC, Amsterdam

Towards routine HPA-screening in pregnancy to prevent FNAIT: Assessing disease burden, optimizing risk group selection and safety of IVIg treatment (LSBR 1440)
Project leader: Prof. Dick Oepkes, Dept. of Obstetrics, LUMC, Leiden, Prof. C. Ellen van der Schoot (co-applicant), Dept. of Experimental Immunohematology, Sanquin, Amsterdam and Prof. Masja de Haas (co-applicant), Dept. of Translational Immunohematology, Sanquin, Amsterdam and Dept. of Immunohematology and Blood Bank, LUMC, Leiden

Assembling the molecular machinery of coagulation: learning from the adaptive evolution of snake venom proteins (LSBR 1451)
Project leader: Dr Mettine H.A. Bos, Dept. Thrombosis and Hemostasis, LUMC, Leiden


Grants 2013

Role of platelet Toll-like receptor signaling in hemostasis and inflammation (LSBR 1309)
Project leader: Prof. Tom van der Poll, Center of Experimental and Molecular Medicine, Academic Medical Center, Amsterdam

Local ubiquitylation contrals vascular integrity and inflammation (LSBR 1311)
Project leader: Prof. Peter L. Hordijk, Sanquin Research, Dept. Molecular Cell Biology, Sanquin Research, Amsterdam (Aug. 2014 – Dec. 2015), Dept. of Physiology, VUmc, Amsterdam (Jan. 2016 – July 2017)

Large scale discovery of leukemia specific minor histocompatibility antigens valuable for immunotherapy of hematological tumors (LSBR 1331)
Project leader: Dr Mirjam H.M. Heemskerk, Dept. of Hematology, LUMC, Leiden

SMIM1, the VEL-antigen, a novel regulator of erythropoiesis (LSBR 1351)
Project leader: Prof. C. Ellen van der Schoot, Dept. of Experimental Immunohematology, Sanquin, Amsterdam, co-applicants: Prof. W.H. Ouwehand, Dept. of Medicine, Cambridge, United Kingdom and Dr Emile van den Akker, Dept. Hematopoiesis, Sanquin Amsterdam

Tracing human dendritic cell development from a common precursor of dendritic cells and osteoclasts (LSBR 1355)
Project leaders: Prof. Jannie Borst and Dr Yanling Xiao, Dept. of Immunology, Netherlands Cancer Institute, Amsterdam

What keeps tumor infiltrating T cells from being effector cells? (LSBR 1373) FELLOWSHIP
Project leader: Dr Monika Wolkers, Dept. of Hematopoiesis, Sanquin Research, Amsterdam

Sanquin Research Program Grant
Molecular and Cellular Haematology Research Program Sanquin Blood Supply
Towards rational improvements in transfusion medicine, adoptive cellular therapy and the treatment of clotting disorders (LSBR 2013-0628)

Project leader: Prof. René A.W. van Lier, scientific director Sanquin Research, Amsterdam


Grants 2012

Dissection of immunomodulatory mechanisms affecting adoptive transfer of peripheral blood derived-tumor reactive T cells in combination with low-dose IFN-alpha as treatment for advanced melanoma (LSBR 1207)
Project leader: Dr ir. Els M.E. Verdegaal, Dept. of Clinical Oncology, LUMC, Leiden, Prof. Sjoerd. H. van der Burg (co-applicant), Dept. of Clinical Oncology, LUMC, Leiden, Prof. Dr. John B.A.G. Haanen (co-applicant), Dept. of Medical Oncology, Netherlands Cancer Institute, Amsterdam

Neutrophil cytotoxic granules in microbial infection and cancer (LSBR 1223)
Project leader: Prof. Timo K. van den Berg, Dept. Blood Cell Research, Sanquin Research, Amsterdam

Understanding clinically significant allo- and auto-immunity towards blood cells (LSBR 1229)
Project leader: Dr Gestur Vidarsson, Dept. of Experimental Immunohematology, Immunoglobulin research lab Sanquin Research, Amsterdam

From in vitro erythropoiesis to transfusion (LSBR 1238) FELLOWSHIP
Project leader: Dr Emile van den Akker, Dept. of Hematopoiesis, Sanquin Research, Amsterdam.

Control of erythropoiesis by iron-dependent expression of protein isoforms (LSBR 1239)
Project leader: Dr Marieke von Lindern, Dept. of Hematopoiesis, Sanquin Research, Amsterdam

Gatekeepers of the vasculature; regulation of exocytosis by syntaxin binding proteins (LSBR 1244)
Project leader: Dr ir. Ruben Bierings, Dept. of Plasma Proteins, Sanquin Research, Amsterdam


Grants 2011

Mesenchymal stromal cells and hematopoietic stem cell transplantation: “from bench to bedside” (LSBR 1101) FELLOWSHIP
Project leader: Dr Carlijn Voermans, Dept. of Hematopoiesis and Immunopathology, Sanquin Research, Amsterdam.

The effects of Hypoxia-inducible factor 1α (Hif-1α) on the development of hemogenic endothelium, hematopoietic stem cells and the supportive microenvironment (LSBR 1109)
Project leader: Prof. Elaine Dzierzak, Dept. of Cell Biology, Stem Cell Institute, Erasmus Medical Center, Rotterdam

Epigenetics in neutrophil biology: from transcriptome to granulocyte transfusions (LSBR 1121)
Project leader: Prof. Taco W. Kuijpers, Dept. of Pediatrics, Academic Medical Center, Amsterdam

Regulation of functional differences between cord blood versus adult peripheral blood innate cells (LSBR 1128)
Project leader: Prof. Reina E. Mebius, Dept. of Molecular Cell Biology and Immunology, VU Medical Center, Amsterdam

Next Generation Sequencing in extremes to identify functional genetic variants affecting red blood cell volume (LSBR 1133)
Project leader: Prof. Pim van der Harst, Dept. of Genetics, University Medical Center Groningen, Groningen

Blood and Beyond: improving properties of human virus-specific CD8+ T cells for adoptive immunotherapy (LSBR 1136)
Project leader: Prof. René A.W. van Lier, Dept. of Hematopoiesis, Adaptive Immunity Lab, Sanquin Research, Amsterdam

Selective mRNA translation controls erythropoiesis; regulation and function of the RNA-binding protein Csde1 (LSBR 1140)
Project leader: Dr Marieke von Lindern, Dept. of Hematopoiesis, Sanquin Research, Amsterdam


Grants 2010

Dynamic fibrin clot formation: a haemostatic process involving multiple blood components and a possible surrogate end point for transfusion (LSBR 1006)
Project leader: Prof. Johan W. M. Heemskerk, Dept. of Biochemistry, CARIM, Maastricht University

T cell modulation of hematopoiesis (LSBR 1014) FELLOWSHIP
Project leader: Dr Martijn A. Nolte, Dept. of Hematopoiesis, Adaptive Immunity Lab, Sanquin Research, Amsterdam

Neutrophil killing: a reappraisal of granulocyte transfusions for patients with fungal infections (LSBR 1019)
Project leader: Prof. Taco W. Kuijpers, Dept. of Pediatrics, Academic Medical Center, Amsterdam

Role of the microtubule network in the generation and expansion of the first hematopoietic stem cells (LSBR 1025)
Project leader: Dr ir. Niels Galjart, Dept. of Cell Biology & Genetics, Erasmus MC, Rotterdam and Dr Catherine Robin (co-applicant), Hubrecht Institute, Utrecht

The molecular basis of leukocyte transendothelial migration: from intracellular GEFs to intercellular gaps (LSBR 1028) FELLOWSHIP
Project leader: Dr Jaap D. van Buul, Dept. of Molecular Cell Biology, Sanquin Research, Amsterdam

Amelioration of sickle cell disease and β-thalassemia: reactivation of γ-globin gene expression (LSBR 1040)
Project leader: Dr Thamar Van Dijk, Dr. J.N.J. Philipsen (co-applicant), Prof. F. Grosveld (co-applicant), Dept. of Cell Biology, Erasmus MC, Rotterdam


Grants 2009

The impact of cholesterol metabolism on megakaryopoiesis and platelet production (LSBR 0912) FELLOWSHIP
Project leader: Dr Suzanne J.A. Korporaal, Dept. of Clinical Chemistry and Haematology, University Medical Center Utrecht and Prof. Miranda van Eck, Division Biopharmaceutics, LACDR, Leiden


Grants 2008

Genome Wide Association Study (GWAS) to identify genetic risk factors for blood group alloimmunisation (LSBR 0820)
Project leader: Prof. C.E. van der Schoot, Dept. of Experimental Immunohematology, Sanquin, Amsterdam, Prof. W.H. Ouwehand (co-applicant), Dept. of Medicine, Cambridge, United Kingdom) and Prof. A. Brand (co-applicant), Transfusion Medicine, LUMC, Leiden